烟草吸烟者的一夜禁欲,腹地-腹地-岛屿连接和三维人格特征
Yu Chen1, Chiang-Shan R Li1,2,3,4
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA.
Journal of integrative neuroscience
|May 31, 2023
概括
在吸烟者中,一夜之间戒烟增加了腹状条纹体-岛屿连接. 功能连接的这种变化与较低的避免伤害的个性特征有关,这表明吸烟风险的神经标志物.
科学领域:
- 神经科学是一个神经科学.
- 成研究 研究成研究
- 精神病学是一个精神病学.
背景情况:
- 人格特征影响吸烟风险和尼古丁成.
- 狭性静止状态功能连接 (rsFC) 被尼古丁剥夺改变.
- 条状RSFC的短期变化及其与人格的关系仍然不清楚.
研究的目的:
- 在一夜之间戒烟后,调查条状RSFC的变化.
- 检查这些rsFC变化与人格特征之间的关系.
主要方法:
- 28名吸烟者在腹期间和过夜戒烟后接受了fMRI扫描.
- 使用标准化问卷 (Fagerström,TPQ) 评估尼古丁依赖和人格.
- 分析的rsFC改变了腹状条纹体 (VS) 和背状条纹体 (DS).
主要成果:
- 与腹相比,戒断后观察到增加的VS-insula rsFC.
- 没有发现DS rsFC的显著变化.
- VS-insula rsFC的增加与危害避免得分有负相关性.
结论:
- 在短期禁烟的情况下,发生状连接性变化.
- VS-insula rsFC变异与人格特质有关,例如避免伤害.
- 在早期戒烟中将神经标记与人格风险因素联系起来.
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