人类大脑功能上的几何约束
James C Pang1, Kevin M Aquino2,3, Marianne Oldehinkel4
1The Turner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging, Monash University, Clayton, Victoria, Australia. james.pang1@monash.edu.
Nature
|May 31, 2023
概括
大脑的几何,不仅仅是连接,也影响大脑的功能. 这项研究揭示了大脑活动源于大脑形状的共振模式,
科学领域:
- 神经科学
- 计算神经科学
- 神经成像
背景情况:
- 经典观点认为大脑功能是由专门的神经元群体及其复杂的连接驱动的.
- 神经场理论表明大脑几何可能是大脑动态的一个更基本的约束.
研究的目的:
- 研究大脑几何与区域间连接在限制大脑功能的作用.
- 使用人类神经成像数据测试神经场理论的预测.
主要方法:
- 在自发和任务唤起条件下对人体磁共振成像 (MRI) 数据的分析.
- 模拟大脑活动作为几何共振模式的激发.
- 在1万多个大脑地图中检查任务唤起的激活.
主要成果:
- 皮层和皮层下活动是由大脑几何学的共振模式解释的, 挑战复杂连接的首要性.
- 激发整个大脑的波长超过60毫米,
- 波形活动动态解释了几何与功能之间的联系, 再现了大脑记录的时空特性.
结论:
- 在塑造大脑功能的过程中,
- 研究结果支持一个统一的,以物理原理为基础的全大脑动态模型.
- 挑战神经科学中关于神经动态驱动力的普遍范式.
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