在健康参与者进行的双盲安慰剂对照研究中,MDMA和LSD联合使用的急性影响
Isabelle Straumann1,2, Laura Ley1,2, Friederike Holze1,2
1Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
概括
将MDMA与LSD结合起来并没有提高心理治疗的主观效应的质量. 而这种组合会延长LSD的时间.
科学领域:
- 心理药理学 心理药理学
- 神经科学是一个神经科学.
- 临床精神病学 临床精神病学
背景情况:
- 对用于精神病学的 lysergic acid diethylamide (LSD) 兴趣重新增长.
- 迷幻药的积极的急性主观效应与长期的治疗效益相关.
- 3,4-甲基二氧化甲胺 (MDMA) 已知具有积极的主观效应和与LSD (糖果翻转) 的娱乐性共同使用.
研究的目的:
- 调查是否同时使用MDMA会增加LSD的急性主观效应.
- 评估MDMA对LSD的安全性和药理动力学特性的影响.
主要方法:
- 双盲,随机,安慰剂控制,交叉设计.
- 24名健康受试者 (12名女性,12名男性).
- 将MDMA (100mg) +LSD (100μg) 与单独使用MDMA,单独使用LSD和安慰剂进行比较;评估主观,自主,内分泌影响和药理动力学.
主要成果:
- 同时使用MDMA并没有改变LSD急性主观效应的质量.
- 与单独使用任何一种物质相比,LSD + MDMA的组合延长了急性主观效应的持续时间.
- 与单独使用LSD相比,LSD + MDMA增加了生理反应 (血压,心率,瞳孔大小) 和催产素水平.
- 随着MDMA的同时使用,观察到更高的血度 (Cmax,AUC) 和更长的LSD半衰期.
结论:
- 与LSD同时使用MDMA并没有改善LSD的急性主观效应或安全性.
- 在迷幻药辅助疗法中,MDMA和LSD的组合不太可能比LSD单一疗法提供显著的优势.
- 进一步的研究可能会探索特定的治疗上下文,但目前的发现并不支持常规组合以获得更好的结果.
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