在社区环境中抗生素耐药性的选择减少,尽管受到额外抗生素的压力,但仍保持不变
Peiju Fang1, Alan Xavier Elena1, Maxi Antonia Kunath1
1Technische Universität Dresden, Institute of Hydrobiology, Zellescher Weg 40, Dresden, Germany.
ISME communications
|May 31, 2023
概括
微生物群落可以减少抗生素耐药性选择,即使暴露于多种抗生素. 尽管第二种抗生素破坏了社区,但这种保护作用仍然存在,这表明特定的相互作用是关键.
科学领域:
- 微生物学 微生物学
- 进化生物学 进化生物学
- 环境科学 环境科学
背景情况:
- 对单个抗生素隔离的抗生素耐药性选择得到了充分记录.
- 复杂的微生物群落可以减轻抗生素耐药性的选择.
- 环境细菌经常遇到复杂的抗生素混合物.
研究的目的:
- 调查第二种选择性剂如何影响抗生素耐药性选择动态.
- 评估废水社区在双重抗生素压力下调节选择中的作用.
- 了解社区环境影响抗性选择的机制.
主要方法:
- 使用的同源性大肠杆菌菌株不同于单一的耐药性决定因素.
- 暴露在抗生素梯度下的菌株,在存在或缺少模型废水社区的情况下.
- 引入了第二种针对社区但不是焦点菌株的抗生素.
主要成果:
- 与基培养相比,社区的存在始终降低了选择系数.
- 第二种抗生素减少了社区活动和多样性,但并没有消除其减少选择的能力.
- 选择减少维持在与单抗生素条件相比的水平.
结论:
- 社区环境减轻了抗生素耐药性选择,即使在双重抗生素压力下.
- 保护作用很可能是由于特定的相互作用而不是一般的竞争.
- 这些发现对了解环境环境中多药耐药性的演变有意义.
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