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相关概念视频

Protein Networks02:26

Protein Networks

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Regulation of Metabolism01:19

Regulation of Metabolism

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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Overview of Metabolism01:40

Overview of Metabolism

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Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Overview of Protein Metabolism01:21

Overview of Protein Metabolism

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Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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相关实验视频

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Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
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代谢网络:权重基因相关性网络分析

Lise Desquilles1, Orlando Musso2

  • 1INSERM, INRAE, Univ Rennes, Nutrition Metabolisms and Cancer, Rennes, France.

Methods in molecular biology (Clifton, N.J.)
|May 31, 2023
PubMed
概括

重量基因关联网络分析 (WGCNA) 识别了与特定生物功能相关的基因网络. 这种方法指导了WGCNA网络的创建,用于表型相关研究.

科学领域:

  • 系统生物学 系统生物学
  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.

背景情况:

  • 重量基因关联网络分析 (WGCNA) 是构建基因网络的强大方法.
  • 了解基因相互连接对于识别生物功能和样本差异至关重要.

研究的目的:

  • 为建立WGCNA网络提供详细,逐步的方法.
  • 将WGCNA网络与特定感兴趣的现象型联系起来.

主要方法:

  • 使用权重基因相关网络分析 (WGCNA) 来构建权重基因网络.
  • 代表网络内的基因之间的直接相互连接.
  • 将网络模块与表型数据联系起来.

主要成果:

  • 成功生成了一个与表型相关的WGCNA网络.
  • 确定了与生物功能和核心功能差异相关的基因模块.
  • 演示了WGCNA对表型驱动网络构建的实用性.

结论:

  • 描述的方法为WGCNA网络建设提供了一个明确的途径.
  • WGCNA促进了生物相关基因模块的发现.
关键词:
脂肪肝疾病是一种脂肪肝疾病.肝癌是一种肝癌.文字转录学 (Transcriptomics) 是一个学科.瘤异质性 瘤异质性

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  • 结果可以被可视化 (例如,Cytoscape) 并用于进一步的功能丰富分析.