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胰腺移植仅在美国,我们站在哪里?

Mahmoudreza Moein¹, Sarah Papa¹, Amin Bahreini¹

¹Division of Transplant Services, Department of Surgery, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA.

World journal of surgery

|May 31, 2023

概括

胰腺移植单独的生存率从2000-2009年到2010-2020年有所改善. 尽管有进展,但胰腺移植本身在美国仍未得到充分利用.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
移植移植移植移植
免疫学免疫学免疫学

背景情况:

在全球范围内进行了超过63,000次胰腺移植手术.
胰腺移植 (PTA) 仅占所有胰腺移植的8%.
在美国,PTA的使用不足.

研究的目的:

量化美国仅胰腺移植的结果.
分析PTA的移植和患者存活率.
比较两个不同的时间段 (2000-2009年与2010-2020年) 的结果.

主要方法:

追溯注册表分析. 追溯注册表分析.
使用了器官采购和移植网络/器官共享联合网络 (OPTN/UNOS) 数据库.
对2000-2009年和2010-2020年期间进行的PTA结果进行比较.

主要成果:

包括3008名全移植接收者.
五年整体移植存活率从52.17% (2000-2009) 增加到58.82% (2010-2020) (P=0.02). 这是一个很大的变化.
患者的5年生存率略有增加,不显著,从74.52%增加到74.92% (P=0.81).

结论:

胰腺移植单独使用,由于手术技术的进步,器官的保存和免疫抑制,所有移植的存活率有所改善.
尽管有所改善,但胰腺移植单独在美国仍未得到充分利用.
进一步的研究和改进的器官分配策略可能会提高PTA的利用率和结果.

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