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相关概念视频

Antigen Processing Pathways01:31

Antigen Processing Pathways

1.1K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
1.1K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

568
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
568
Mitochondrial Precursor Proteins01:39

Mitochondrial Precursor Proteins

2.6K
Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70  chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial...
2.6K

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相关实验视频

Updated: Jul 28, 2025

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

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NetCleave:一种开源算法,用于预测MHC-I和MHC-II的C端抗原处理.

Roc Farriol-Duran1, Marina Vallejo-Vallés1, Pep Amengual-Rigo1

  • 1Barcelona Supercomputing Center (BSC), Barcelona, Spain.

Methods in molecular biology (Clifton, N.J.)
|May 31, 2023
PubMed
概括

这项研究介绍了NetCleave的管道,NetCleave是一种预测C端抗原处理的算法. 这有助于通过了解表位素生成来设计有效的基于的疫苗接种策略.

关键词:
处理抗原处理.生物信息学是一种生物信息学.皮层预测器的预测器哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈免疫系统的免疫系统.免疫信息学是指免疫信息学.在MHC-I中,MHC-I是最重要的.在MHC-II中,MHC-II是最常见的.神经网络的神经网络的神经网络在T细胞,T细胞.

更多相关视频

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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Published on: October 15, 2021

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相关实验视频

Last Updated: Jul 28, 2025

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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科学领域:

  • 免疫学 免疫学 免疫学
  • 计算生物学 计算生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • T 细胞表位表现涉及复杂的抗原处理.
  • C端处理是生成表现表征的表征物的一个关键瓶.
  • 准确预测C端处理对于基于的疫苗设计至关重要.

研究的目的:

  • 为利用NetCleave算法提供一个全面的管道.
  • 为了提高对MHC-I和MHC-II通路的C端抗原处理的预测.
  • 为了利用NetCleave的能力来改善疫苗开发.

主要方法:

  • 开发一个计算管道来利用NetCleave的功能.
  • 应用NetCleave用于预测C端切割点.
  • 在预测中整合MHC-I和MHC-II路径的考虑.

主要成果:

  • 该管道有效地利用了NetCleave的预测能力.
  • 证明了该算法的实用性,以了解C-终端表位生成.
  • 为免疫学和疫苗学研究人员提供了一个工具.

结论:

  • 网Cleave管道为预测C端抗原处理提供了宝贵的资源.
  • 这种方法可以大大促进基于的疫苗的合理设计.
  • 由于NetCleave的开源和可回收性质,这有助于进一步的研究和应用.