人体血中减缓生理衰老的代谢学特征
Georges E Janssens1,2, Lotte Grevendonk3,4, Bauke V Schomakers5,6
1Laboratory Genetic Metabolic Diseases, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands. g.e.janssens@amsterdamumc.nl.
GeroScience
|May 31, 2023
概括
我们开发了PhysiAge,这是一个使用可访问的健康数据来测量生物衰老的新得分. 这一分数更好地预测死亡率,并识别与衰老过程缓慢相关的代谢特征.
科学领域:
- 老年学和长寿科学 老年学和长寿科学
- 衰老的生物标志物
- 代谢学和衰老研究研究
背景情况:
- 老龄化增加了疾病的风险,推动了人们对健康长寿的干预措施的兴趣.
- 目前评估生物衰老的方法往往复杂且难以获得.
- 需要简单,可解释的生物衰老得分,供公众使用.
研究的目的:
- 开发和验证 PhysiAge,一个可访问的生理衰老评分.
- 评估PhysiAge对死亡率和衰老标志物的预测能力.
- 用PhysiAge. 来识别与衰老减速相关的代谢特征.
主要方法:
- 使用五个可访问的参数开发了PhysiAge:每日步数,血糖,静脉压,性别和年龄.
- 比较了PhysiAge对死亡率的预测准确度与时间表年龄.
- 分析了老年人的血代谢概况,以发现与PhysiAge的关联.
主要成果:
- 与单独的时间年龄相比,PhysiAge显示出更好的死亡率预测.
- 身体年龄与已知的衰老标志物相关,包括NAD+水平,氧化应激和身体功能.
- 确定了减缓衰老的代谢特征,包括TCA循环的成分,如酸盐,酸盐和异酸盐.
结论:
- PhysiAge提供了一个可访问的工具,用于跟踪和潜在地干预衰老轨迹.
- 血中的特定代谢特征与衰老减缓有关.
- 对已识别的代谢特征进行进一步的研究可以阐明人类衰老中的因果作用.
关键词:
老化的时钟钟.老龄化干预措施 干预措施酸的使用方法健康的长寿健康的长寿异酸盐是一种异酸盐.马拉酸盐是什么意思 马拉酸盐代谢学 代谢学 代谢学物理年龄 物理年龄生理老龄化 生理老龄化在TCA循环中,TCA循环是更多相关视频
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