尿路前素在肺炎诊断中的实用性:一个横截面研究
Ryo Yamashita1, Yusuke Izumi2, Koji Nakada3
1Department of General Medicine, The Jikei University School of Medicine, Daisan Hospital, 4-11-1 Izumihoncho, Komae-Si, Tokyo, 201-0003, Japan. ryoyamashita@jikei.ac.jp.
BMC infectious diseases
|May 31, 2023
概括
与其他病症相比,发炎患者的尿液前素水平明显高于其他病症. 测量尿路前素可以帮助区分肌炎与非肌炎疾病.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 传染性疾病 传染性疾病
- 生物标志物 生物标志物
背景情况:
- 普雷塞普辛是一种生物标志物,由细菌细胞在细菌细胞分裂过程中产生的.
- 升高的普雷塞普辛表明感染部位,但其在尿路感染中的作用仍然不清楚.
研究的目的:
- 调查尿路前素在区分肌炎与非肌炎疾病中的诊断效用.
- 评估尿液中的普雷塞普辛水平是否可以作为炎炎的可靠生物标志物.
主要方法:
- 一项横截面研究比较了皮叶龙炎患者和没有皮叶龙炎患者的尿液前素水平.
- 统计分析包括曼-惠特尼测试和接收器操作特征 (ROC) 曲线分析.
主要成果:
- 尿中的普雷塞水平在炎症组 (2232.0 pg/mL) 显著高于非炎症组 (1348.0 pg/mL) (P=0.023).
- 在ROC分析中,发现切割值为3650 pg/mL,具有高特异性 (0.96),用于诊断炎炎.
- 该测试显示了0.93的正预测值和0.52的负预测值.
结论:
- 尿路前素测量是区分皮叶龙炎和其他疾病的宝贵工具.
- 高特异性表明,尿路前素在升高时是一种强有力的指标,有助于诊断肌炎.
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