急性胰腺炎重症监护病房患者的胸部外周止痛:EPIPAN多中心随机对照试验
Matthieu Jabaudon1,2, Alexandra Genevrier3, Samir Jaber4,5
1Department of Perioperative Medicine, CHU Clermont-Ferrand, 58 Rue Montalembert, 63000, Clermont-Ferrand, France. mjabaudon@chu-clermontferrand.fr.
胸部外周止痛药并没有改善急性胰腺炎重症监护室患者的结果. 这项随机试验在无呼吸器的日子中没有发现显著差异,这表明该干预措施需要进一步的安全研究.
科学领域:
- 临界护理医学 临界护理医学
- 疼痛管理 疼痛管理
- 胃肠病学 胃肠病学
背景情况:
- 临床前研究和试点试验表明,外周止痛可能有利于急性胰腺炎.
- 胸部外周止痛正在作为严重胰腺炎的常规护理的辅助研究中.
研究的目的:
- 评估胸部外周止痛疗法在改善急性胰腺炎重症监护室 (ICU) 患者的临床结果方面的疗效.
主要方法:
- 进行了一项多中心,开放标签,随机对照试验.
- 患有急性胰腺炎的成年ICU患者随机分配到胸部外周止痛加常规护理或仅常规护理.
- 主要结局是30天内的无呼吸器日.
主要成果:
- 该研究包括135名患者;65人接受了干预,70人接受了通常的护理.
- 两组之间没有观察到无呼吸器日数的显著差异 (两组均平均30天).
- 干预组的入侵通风持续时间较长 (14天与6天相比,p=0.02).
结论:
- 胸部外周止痛疗法在这种多中心随机试验中对急性胰腺炎的ICU患者没有显示好处.
- 在这种患者群体中,外围止痛的安全性需要进一步研究.
- 这些发现特别适用于低输管要求的患者.
更多相关视频
04:01Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis
Published on: September 8, 2022
06:05Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis
Published on: January 27, 2023
相关概念视频
Acute Pancreatitis II: Clinical Manifestations and Management
Chronic Pancreatitis II: Collaborative Care
Assessment:
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Endoscopic Procedures V: ERCP
Patient...
