中国支气管切除症儿童的病因学和临床特征:10年多中心回顾性研究
Hao Wang1,2, Bao-Ping Xu1,2, Yan-Min Bao3
1Beijing Children's Hospital, Capital Medical University, Beijing, China.
The clinical respiratory journal
|June 1, 2023
概括
这项研究确定了后感染性原因,原发性免疫缺陷和原发性动障碍 (PCD) 作为中国儿童支气管病的常见病因. 临床特征可以帮助指出特定的潜在原因.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 医学病因学研究 医学病因学研究
背景情况:
- 儿童的支气管切除症是一个重大的临床挑战.
- 了解各种原因和临床特征对于有效管理至关重要.
研究的目的:
- 为了研究中国儿童支气管切除症的病因谱.
- 描述临床表现和高分辨率计算机断层扫描 (HRCT) 的发现.
主要方法:
- 一项多中心的回顾性研究,涉及中国13个中心的193例儿科病例 (2008-2017年).
- 包括需要由两个放射科医生确认的临床和HRCT诊断标准.
- 对符合特定标准的注册病例进行了数据分析.
主要成果:
- 在87%的病例中确定了潜在的病因,最常见的是感染后原因 (46%),原发性免疫缺陷 (14%),以及原发性纤毛功能障碍 (PCD) (13%).
- 常见的症状包括咳,吐和发烧在恶化期间;19%的运动耐受性有限,30%的生长受限.
- 在126例病例中,HRCT揭示了扩散性支气管切除,主要影响下侧和右侧中叶;在约30%的病例中发现了阳性培养.
结论:
- 在中国,大多数儿科支气管病例都有可识别的潜在病因.
- 感染后的原因,原发性免疫缺陷和PCD是主要的贡献者.
- 特定的临床表现可能表明特定的病因起源.
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