Cichorium intybus L. 毛发根作为抗菌活性平台
Suvi T Häkkinen1, Katarina Cankar2, Liisa Nohynek1
1VTT Technical Research Centre of Finland Ltd., Tietotie 2, 02044 Espoo, Finland.
Pharmaceuticals (Basel, Switzerland)
|June 1, 2023
概括
一种新的植物细胞培养物 - - 香草毛状根,对人类微生物具有显著的抗菌活性,包括对甲基西林耐药的金黄色葡萄球菌 (Staphylococcus aureus). 这表明它们有可能生产有价值的抗微生物化合物.
科学领域:
- 植物生物技术 植物生物技术
- 药理学是指药理学,即药理学是指药理学.
- 微生物学 微生物学
背景情况:
- 工业 (Cichorium intybus) 是为了获得食纤维和生物活性二次代谢产物而种植的.
- 毛发根是一种植物细胞培养,被认为可以生产有价值的植物性分子.
- 评估抗微生物药物的新来源对公共卫生至关重要.
研究的目的:
- 为了建立工业草毛的根植文化.
- 为了评估这些毛的根提取物的抗菌潜力.
- 为了比较抗微生物活性与常规根的抗微生物活性.
主要方法:
- 建立工业草毛发根培养.
- 制备热水提取物从毛的根和树根.
- 抗菌活性测定针对相关的人类微生物病原体.
主要成果:
- 草毛发根提取物对测试的人类微生物表现出显著的抗菌活性.
- 传统的草根提取物没有显著的抗菌活性.
- 值得注意的是,香草毛发的根提取物对抗抗甲素耐药黄金葡萄球菌 (MRSA) 具有强烈活性.
结论:
- 工业毛根是一种有前途的生物技术系统,用于生产抗菌化合物.
- 毛发根培养为抗菌剂生产提供了传统植物来源的可行替代方案.
- 鉴定到的抗菌性质突出显示了花毛发根在制药应用中的潜力.
相关概念视频
Surface Membrane Barriers
1.2K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.2K
Hand hygiene
3.4K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
3.4K
Antimicrobial Effectiveness
98
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
98


