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在心血管疾病中对巨细胞极化进行表观遗传调节

Sumra Komal¹, Sheng-Na Han¹, Liu-Gen Cui¹

¹Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.

Pharmaceuticals (Basel, Switzerland)

|June 1, 2023

概括

表观遗传修饰会影响巨细胞的两极分化,这是心血管疾病 (CVD) 的关键因素. 了解这些变化为新的表观遗传疗法提供了潜在的机会,以对抗心脏病的进展和死亡率.

科学领域:

心血管生物学心血管生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
免疫学免疫学免疫学

背景情况:

心血管疾病 (CVD) 是全球主要的健康问题,导致大量住院治疗和死亡.
慢性炎症和巨细胞透对于心血管疾病的发病和进展至关重要.
表观遗传修饰调节心肌细胞功能和巨细胞两极分化,影响心脏病的发展.

研究的目的:

审查影响心血管疾病中巨细胞两极分化的关键表观遗传修饰.
探索这些修改在心脏病病理生理学中的作用.
突出潜在的表观遗传疗法对心血管疾病.

主要方法:

关于表观遗传修饰和心血管疾病的最新数据的文献综述.
分析DNA甲基化,基因素修饰和RNA修饰的作用.
检查心脏巨细胞两极分化及其对疾病的贡献.

主要成果:

表观遗传修饰显著影响心肌细胞功能和巨细胞两极分化.
这些修改涉及炎症反应,组织修复和心血管疾病的重塑.
特定的表观遗传机制有助于动脉样硬化,心肌损伤和心力衰竭的病理生理学.

结论:

表观遗传修饰是心血管疾病发展和进展的关键调节者.
准心脏巨细胞中的表观遗传机制是一个有希望的治疗策略.
对表观遗传疗法的进一步研究可能会导致对心血管疾病的先进治疗方法.

关键词:

这是一种N6-甲基氨酸.心血管疾病心血管疾病表观遗传学是指表观遗传学.巨细胞的两极分化没有编码的RNAs.

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