恩帕格利弗洛辛 保护对哈洛佩里多尔实验诱导的卵巢毒性
Walaa Yehia Abdelzaher1, Michel De Waard2,3,4, Alyaa Abdelfattah Abdelmonaem1
1Department of Pharmacology, Faculty of Medicine, Minia University, Minia 61511, Egypt.
Pharmaceuticals (Basel, Switzerland)
|June 1, 2023
概括
恩帕格利弗洛辛 (EMPA) 通过减少炎症,氧化应激和亡来保护大鼠免受皮醇诱导的卵巢损伤. 这项研究突出了EMPA的重点.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- 利 (HAL) 是一种具有已知的毒性作用的抗精神病药物.
- 卵巢损伤是HAL治疗的潜在副作用.
- 恩帕格利弗洛辛 (EMPA) 具有抗炎,抗氧化和抗位性质.
研究的目的:
- 在雌性大鼠中研究EMPA对HAL诱导的卵巢损伤的保护作用.
- 探索涉及氧化应激,炎症和亡的潜在机制.
主要方法:
- 成年雌性大鼠被分为四组:对照组,EMPA,HAL和HAL + EMPA.
- 评估了荷尔蒙特征 (FSH,LH,AMH),卵巢氧化应激,炎症和亡生物标志物.
- 评估了卵巢组织病理学和热冲击蛋白70 (Hsp70) 表达.
- 分析了Sirtuin-1 (Sirt-1) 表达的情况.
主要成果:
- HAL的使用显著增加了FSH,LH和卵巢氧化应激,炎症和亡标志物.
- HAL治疗降低了AMH水平,Sirt-1表达,并导致卵巢组织病理损伤与高Hsp70免疫表达.
- 管理EMPA显著正常化了荷尔蒙水平,生物标志物,改善了他的病理学,并减少了Hsp70表达.
结论:
- 在老鼠中,EMPA证明了对HAL诱导的卵巢毒性有保护作用.
- 这种保护机制涉及Sirt-1/Hsp70/TNF-α/caspase-3信号通路的调节.
- EMPA可能是减轻与HAL相关的卵巢损伤的潜在治疗剂.
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