概述含有1,2,3-triazole的混合物及其潜在的抗胆酶活性
Shah Alam Khan1, Mohammad Jawaid Akhtar1, Urvashee Gogoi2
1College of Pharmacy, National University of Science and Technology, Muscat 130, Oman.
Pharmaceuticals (Basel, Switzerland)
|June 1, 2023
概括
1,2,3-triazole化合物显示出作为胆酶抑制剂治疗神经退行性疾病的承诺,通过提高乙胆水平. 本综述涵盖了合成和混合抗胆酶潜力.
科学领域:
- 药用化学 医学化学
- 神经科学是一个神经科学.
- 有机合成 有机合成
背景情况:
- 乙胆 (ACh) 对认知功能至关重要,其耗尽与阿尔茨海默氏症等神经退行性疾病 (ND) 有关.
- 胆酶抑制剂增加了ACh水平,为NDs提供了症状缓解.
- 1,2,3-二醇是一种具有多样化的生物活动的多功能支架,越来越多地用于药物发现.
研究的目的:
- 对1,2,3-triazole化合物的合成策略进行审查.
- 要突出1,2,3-三醇混合物 (2015-2022) 的抗胆酶潜力.
- 强调开发用于NDs的新型胆酶抑制剂的结构特征.
主要方法:
- 对1,2,3-triazoles的合成途径进行文献综述.
- 对报告1,2,3-三醇衍生物抗胆酶活性研究的分析.
- 专注于混合化合物的结构-活性关系.
主要成果:
- 有各种合成方法可以将1,2,3-triazole核心结合起来.
- 许多1,2,3-triazole杂交物表现出显著的乙胆酶 (AChE) 和丁胆酶 (BuChE) 抑制活性.
- 混合化策略已经产生了强大的抑制剂,有可能用于ND治疗.
结论:
- 1,2,3-三醇衍生物代表了一类有前途的化合物,用于开发新的胆酶抑制剂.
- 了解结构-活性关系是优化这些化合物用于NDs治疗的关键.
- 对1,2,3-triazole杂交物的进一步研究可能会导致对认知衰退的改善治疗方法.
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