乳酸在治疗肺部疾病中的潜力
Katarzyna Kaczyńska1, Monika Jampolska1, Piotr Wojciechowski1
1Department of Respiration Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawińskiego 5 St., 02-106 Warsaw, Poland.
Pharmaceuticals (Basel, Switzerland)
|June 1, 2023
概括
乳酸 (LF) 显示出治疗肺部疾病的潜力,人类研究证实了对呼吸道感染的益处. 然而,对肺癌和COVID-19等其他疾病的证据仍然不确,需要进一步研究.
科学领域:
- 生物化学 生化学
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 肺部疾病是全球主要的健康负担,治疗选择有限.
- 乳酸 (LF) 是一种结合铁的葡萄糖蛋白,具有免疫调节,抗炎和抗菌特性.
- 由于其多方面的生物活动,LF被探索为各种肺部疾病的治疗剂.
研究的目的:
- 审查目前关于乳酸铁素在治疗肺部疾病中的有益作用的文献.
- 评估LF作为肺部疾病治疗剂或辅助治疗的疗效.
主要方法:
- 对现有和最新的科学文献进行系统审查.
- 分析了体外,体内和人体临床研究中的乳酸铁素对肺部疾病的影响.
主要成果:
- 在体外和体外研究表明,LF对喘,病毒感染,囊性纤维化和肺癌的效果很强.
- 人类研究证实了LF在减少呼吸道感染和缩短恢复时间方面的有效性.
- 对于LF在肺癌,COVID-19和败血症中的使用存在相互矛盾的结果;对其他肺部疾病的人类数据有限.
结论:
- 乳酸显示出对呼吸道感染的有前途的治疗潜力.
- 需要进一步进行强大的人类临床试验,以确认LF对其他肺部疾病的疗效,包括癌症和病毒感染.
- 肺炎可能作为一种有价值的辅助疗法,但在许多肺部疾病中广泛临床应用仍然需要确的证据.
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