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检查点抑制剂相关的硬化皮质和硬化皮质模仿者.

Michael Macklin1, Sudeep Yadav1, Reem Jan1

  • 1Section of Rheumatology, Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA.

Pharmaceuticals (Basel, Switzerland)
|June 1, 2023
PubMed
概括

免疫检查点抑制剂 (ICI) 可以导致全身性硬化症 (SSc) 和模仿性硬化症. ICI-SSc与初级SSc不同,并且在ICI治疗后,先前存在的SSc可能会爆发.

关键词:
自身免疫性疾病是一种自身免疫性疾病.药物毒性 毒性的药物毒性带炎是一种带炎.免疫检查点抑制剂免疫检查点抑制剂莫菲亚 (Morphea) 是一个形象.系统性硬化症 系统性硬化症

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科学领域:

  • 在瘤学瘤学.
  • 类风湿病学 类风湿病学
  • 免疫学 免疫学 免疫学

背景情况:

  • 免疫检查点抑制剂 (ICI) 是标准的癌症治疗.
  • ICI的使用与自身免疫性并发症有关.
  • 关于ICI相关性硬化症的数据是有限的.

研究的目的:

  • 审查ICI相关的全身性硬化症 (ICI-SSc) 的文献.
  • 分析ICI-SSc和初级SSc之间的差异.
  • 为了调查ICI相关的硬化皮肤模仿.

主要方法:

  • 系统的文献审查.
  • 对ICI-SSc和模拟的案例报告和研究的分析.
  • 对ICI-SSc特征与初级SSc进行比较.

主要成果:

  • 在ICI-SSc病例中,血管特征较少,血清阳性低于初级SSc.
  • 患有先前存在的SSc的患者可能会经历ICI后的爆发.
  • 确定了ICI-eosinophilic fasciitis的病例;没有发现ICI-scleromyxedema和ICI-scleroedema.

结论:

  • ICI-SSc与初级SSc呈现的不同.
  • 对ICI-SSc的管理需要进一步调查.
  • 合作,多机构研究对于理解和管理ICI-SSc至关重要.