通用液体膜用于低或中等水友性基础的电膜提取
Chen Zhou1,2, Samira Dowlatshah1, Anne Oldeide Hay1
1Department of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, 0316 Oslo, Norway.
Analytical chemistry
|June 1, 2023
概括
本研究介绍了电膜提取 (EME) 的通用提取条件,使用分析物电荷和疏水性来选择液体膜. 新的溶剂,如2-undecanone和tripentyl) 酸盐,为制药分析提供了强大的替代品.
科学领域:
- 分析化学 分析化学
- 分离科学 分离科学
- 电化学 电化学 电化学
背景情况:
- 电膜提取 (EME) 是一种样品制备技术.
- 选择最佳的液体膜对于EME效率至关重要.
- 分析物质的特性,如电荷和疏水性,会影响提取.
研究的目的:
- 根据分析物质的特性,建立EME的通用提取条件.
- 识别和评估用于基本制药提取的新型液体膜溶剂.
- 为了确定所选溶剂的操作窗口和稳定性.
主要方法:
- 在EME中选各种有机溶剂作为液体膜.
- 使用90种具有不同疏水性 (log P) 和电荷 (z) 的基本药物作为模型分析物.
- 评估提取效率,运行稳定性,电流水平和潜在的副作用 (气体形成,pH漂移).
主要成果:
- 2-尼托乙烯乙烯 (NPOE) 对单基和双基化合物 (z=+1到+2) 有效,其 log P 为 2.2-6.4.4.
- 2-Undecanone是单基化合物 (z=+1) 的一个强大的替代品,log P为1.0-5.8.8.
- 三酸为基础 (log P 0.5-5.5) 提供了选择性,具有较高电流但稳定的运行.
结论:
- 基于分析物电荷和疏水性的通用提取条件可以指导EME中的液体膜选择.
- 酸二甲和三酸是基本分析物的EME的有希望的新溶剂.
- NPOE,2-undecanone和tripentyl) 酸盐表现出不同的提取机制和选择性概况.
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