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休息状态中半球间协调的变化与精神分裂症中耐火的听觉口头幻觉
Huichang Qian1, Xiaozheng Liu1, Zhongwei Guo1
1School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China (Qian, J. Liu); Department of Radiology, Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China (X. Liu); Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, China (Guo); and Departments of Radiology (Wang), Psychogeriatrics (Chen), and Science and Education (J. Liu), Hangzhou Seventh People's Hospital, Hangzhou, China.
精神分裂症患者具有耐火性听觉语言幻觉,显示大脑连接的改变. 在特定的大脑区域的这种半球间功能失联可能会导致听觉语言幻觉.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 精神分裂症是一种复杂的精神障碍.
- 听觉语言幻觉 (AVHs) 是一个常见和令人痛苦的症状.
- 耐火性AVHs (RAVHs) 是一个重要的治疗挑战.
研究的目的:
- 调查精神分裂症和RAVH患者的静止状态半球间功能连接.
- 使用voxel镜像同位素连接 (VMHC) 来分析大脑功能.
- 探索功能连接和症状严重程度之间的关系.
主要方法:
- 招募了三个组:精神分裂症和RAVH患者 (RAVH组),没有AVH的精神分裂症患者 (非AVH组) 和健康对照.
- 采用VMHC分析来检测同型大脑区域之间功能连接的差异.
- 检查了症状得分和神经学指标之间的相关性.
主要成果:
- 在RAVH和非AVH组中观察到异常的双边连接在上部和中部旋内.
- 在RAVH和健康对照组之间发现了双边连接的差异,在直回,下额回和门.
- 上部和中部时转移中的半球间连接与患者的阳性症状得分相关.
结论:
- 研究结果表明,精神分裂症患者的半球间功能失联.
- 同型大脑区域的失联性可能在AVHs的病理生理学中发挥关键作用.
- 这些结果有助于了解听觉语言幻觉背后的神经机制.
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