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尼古丁胺N-甲基转移酶维持一个核心表观遗传程序,促进乳腺癌转移殖民的转移性殖民

Joana Pinto Couto1,2,3, Milica Vulin1,2,3, Charly Jehanno1,2

  • 1Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.

The EMBO journal
|June 1, 2023
PubMed
概括

尼古丁胺N-甲基转移酶 (NNMT) 通过增强癌细胞可塑性来驱动乳腺癌转移. 抑制NNMT及其下游标,如PRDM5,可显著抑制瘤的扩散并改善结果.

关键词:
没有NNMTMT的乳腺癌 乳腺癌 乳腺癌原蛋白是一种原蛋白.殖民化 殖民化的殖民化转移 转移 转移 转移

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