在阿尔茨海默氏症患者中影响超直流刺激的结果和因素:系统性审查
Rabeet Tariq1, Bhavya Kansal2, Rameen Shaikh3
1Department of Neurosurgery, Liaquat National Hospital and Medical College, Karachi, Pakistan.
Current Alzheimer research
|June 1, 2023
概括
超直流刺激 (tDCS) 可能改善阿尔茨海默病患者的认知状态,执行功能和语言. 结果取决于刺激参数,如极性和区域,对注意力或记忆力没有显著影响.
科学领域:
- 神经调节是一种神经调节.
- 神经科学是一个神经科学.
- 老年医学 老年医学
背景情况:
- 阿尔茨海默病 (AD) 是导致痴呆的主要原因,需要有效的干预措施.
- 目前阿尔茨海默病的治疗方法侧重于管理认知衰退,并正在研究新的治疗方法.
- 超直流刺激 (tDCS) 是一种新兴的非侵入性神经调节技术,具有潜在的认知益处.
研究的目的:
- 系统地审查tDCS对阿尔茨海默病患者认知功能的影响.
- 评估tDCS对一般认知状态,记忆,注意力,执行功能,语言和智商的影响.
- 确定影响AD. tDCS治疗结果的因素.
主要方法:
- 在PubMed,ScienceDirect和Cochrane图书馆数据库中进行系统的文献搜索.
- 纳入标准侧重于双盲,安慰剂控制,随机临床试验 (第三阶段),病例研究和涉及AD患者和tDCS的病例系列.
- 对获取的文章进行选和全文评估,以选择相关研究进行审查.
主要成果:
- 对20项研究的审查表明,在tDCS之后,认知状态,执行功能,工作记忆,识别记忆和语言的潜在改善.
- 效果取决于刺激的极性和目标大脑区域.
- 没有观察到注意力,关联记忆,回忆记忆,视觉空间能力或神经精神症状的显著改善.
结论:
- 超直流刺激 (tDCS) 是一种耐受良好的干预措施,用于增强阿尔茨海默病中的特定认知领域.
- 治疗结果受到关键因素的影响,例如刺激极性,目标大脑区域,会话频率和并发训练协议.
- 需要进一步的研究来优化tDCS协议,以最大限度地提高AD患者的认知效益.
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