欧米茄-3脂肪酸与心律,心率和心房动的变化
Philipp Baumgartner1, Martin F Reiner1, Andrea Wiencierz2
1Department of Internal Medicine Cantonal Hospital of Baden Baden Switzerland.
Journal of the American Heart Association
|June 1, 2023
概括
血中欧米茄-3脂肪酸 (n-3FA) 水平与心房动 (AF) 类型没有强烈的联系. 然而,较高的n-3FA和多可萨赫酸水平可能与AF患者的心率减慢相关.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 之前对omega-3脂肪酸 (n-3FA) 和心房 (AF) 的研究产生了不一致的结果.
- 在已确定的AF患者中,n-3FA血和心律之间的关系尚不清楚.
研究的目的:
- 为了研究总和个体的n-3FA血液水平和AF类型之间的关联.
- 在被诊断为AF的患者中,评估n-3FA血液水平与心率 (HR) 和HR变异性的相关性.
主要方法:
- 在1969年AF患者中测量了总n-3FA,eicosapentaenoic acid,docosahexaenoic acid,docosapentaenoic acid和alpha-linolenic acid的血液水平,这些患者来自SWISS-AF队列.
- 标准后勤和线性回归分析被用来将n-3FA水平与AF类型,HR和HR可变性相关联,并对潜在的混因素进行调整.
主要成果:
- 在n-3FA血液水平和AF类型之间没有发现显著的关联.
- 较高的总n-3FA和多可沙赫酸水平显示出与更慢的HR相关的趋势.
- 多可沙丁酸水平与较低的HR变化三角指数相关.
结论:
- n-3FA的血液水平似乎与AF类型没有强烈的关联.
- 增加的总n-3FA和多可萨赫酸水平可能与AF患者的HR降低相关.
- 多可沙丁酸可能与AF患者的HR波动性降低有关.
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