相关实验视频
Updated: Jul 28, 2025
07:17
Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
Published on: April 14, 2016
84.1K
在慢性疾病中青春期和骨健康
1Department of Endocrinology, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Rd, Parkville, Victoria 3052, Australia. Correspondence to: Dr Margaret Zacharin, Department of Endocrinology, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Rd, Parkville, Victoria 3052, Australia. margaret.zacharin@rch.org.au.
Indian pediatrics
|June 1, 2023
概括
年轻人的慢性疾病会影响成长和青春期,影响骨质峰值,增加成年人骨折风险. 确保正常的青春期发育对于在患有慢性疾病的儿童中实现最佳骨健康至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 骨的新陈代谢 骨的新陈代谢
- 慢性疾病管理 慢性疾病管理
背景情况:
- 儿童和青少年时期的慢性疾病会破坏线性生长和青春期的发展.
- 骨质积累的峰值,主要发生在青春期,是成人骨健康和骨折风险的关键决定因素.
- 性激素在青春期骨质积累中起着至关重要的作用.
研究的目的:
- 突出慢性疾病对年轻人的成长和青春期的不利影响.
- 强调正常的青春期时间的重要性,以实现最佳的峰值骨质量.
- 为了强调青春期发育与慢性病青少年成年人骨折风险降低之间的联系.
主要方法:
- 对儿童群体慢性病,生长,青春期和骨代谢现有文献的综述.
- 分析疾病慢性和青春期状态对骨积累的影响.
- 青春期发育里程碑与长期骨健康结果的相关性.
主要成果:
- 慢性疾病会对线性生长和青春期的开始和进展产生负面影响.
- 青春期是骨质积累的关键时期,性激素显著影响了这一过程.
- 正常的青春期时间和完成 (女孩的女性化,男孩的男性化) 对于最大化峰值骨质量至关重要.
结论:
- 实现最佳骨质量,对于降低成年骨折风险至关重要,取决于患有慢性疾病的青少年的正常青春期发育.
- 旨在确保及时和完整的青春期的干预措施对于改善这一群体的长期骨健康至关重要.
- 解决慢性疾病对青春期进展的影响是减轻未来骨折风险的关键.
相关概念视频
01:29Bone Disorders
3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
01:17Hormones and Bone Tissue
2.8K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.8K
01:09Changes in the Appendicular Skeleton with Age
2.1K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.1K
01:40Bone Remodeling
38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
01:25Role of Vitamins in Maintaining Bone Health
3.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.5K
01:02What is the Skeletal System?
53.0K
Overview
53.0K