Sanguisorba officinalis L.通过由巨细胞介导的炎症反应促进大鼠糖尿病伤口愈合
Jianying Song1,2, Jing Zeng3, Silin Zheng4
1Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Phytotherapy research : PTR
|June 1, 2023
概括
桑吉索巴 (Sanguisorba officinalis L.) 提取物 (ESO) 通过减少炎症,加速糖尿病伤口愈合. 它调节免疫细胞反应并抑制关键的炎症通路,为糖尿病伤口提供了有前途的治疗方法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 香草 (Sanguisorba officinalis L.) 是一种传统的中医药,用于治疗烧伤.
- 在加速糖尿病伤口愈合方面,S. officinalis L. 的有效性尚未得到充分证实.
- 糖尿病伤口表现出异常的炎症和受损的愈合过程.
研究的目的:
- 评估Sanguisorba officinalis L.乙醇提取物 (ESO) 对糖尿病伤口 (DW) 的治疗效果.
- 调查ESO在促进DW治愈方面的潜在机制.
主要方法:
- 进行了体内和体外实验,以评估ESO对DW的影响.
- 分析了关键的炎症性细胞因子 (IL-6,IL-1β,TNF-α,IL-10) 和免疫细胞标记物 (CD86,CD206).
- 在RAW264.7细胞中研究了NF-κB信号通路和NLRP3炎症酶激活.
主要成果:
- ESO显著提高了糖尿病伤口的愈合率.
- 通过ESO治疗减少了促炎性细胞因子,增加了抗炎性细胞因子.
- ESO抑制了化NF-κB的核进入,并抑制了NLRP3炎症组分 (NLRP3,Caspase-1,IL-1β).
- 通过抑制NF-κB/NLRP3通路,ESO促进了M2巨细胞的两极分化.
结论:
- 桑吉索巴 (Sanguisorba officinalis L.) 乙醇提取物 (ESO) 显示出加速糖尿病伤口愈合的显著潜力.
- 通过抑制异常炎症和调节免疫细胞反应,ESO发挥其治疗作用.
- 该机制涉及NF-κB/NLRP3信号通路的抑制,促进向抗炎M2巨细胞表型的转变.
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