艾滋病毒感染者高血压发生率:一项纵向观察性研究
Marco Gelpi1, Luanna Uchoa Karvig1, Andreas Dehlbæk Knudsen1
1Viro-immunology Research Unit, Department of Infectious Diseases, University of Copenhagen, Copenhagen.
AIDS (London, England)
|June 1, 2023
概括
艾滋病毒感染者 (PWH) 的高血压发病率与一般人群相似. 中部肥胖和腰比是关键的风险因素,而不是HIV特定的因素,强调生活方式的改变以预防.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 心血管疾病 (CVD) 是艾滋病毒 (PWH) 感染者的主要死亡原因.
- 高血压是已知的心血管疾病风险因素,但其在PWH中的发生率和预测因子未得到充分研究.
- 了解PWH中高血压的发展对于有效的CVD预防策略至关重要.
研究的目的:
- 为了调查高血压的发病率在良好的治疗PWH.
- 在这个人群中确定事件高血压的预测因素.
- 为了比较PWH与普通人群的高血压风险.
主要方法:
- 分析了来自哥本哈根艾滋病毒共发病率 (COCOMO) 研究的532名PWH队列.
- 参与者接受了基线和2.5年后续检查.
- 使用线性和波松回归模型来评估风险因素,并进行混调整.
主要成果:
- 高血压的发生率为每100个随访人年8.5例.
- 增加的腰比 (aRR 1.54) 和中心肥胖 (aRR 2.29) 与发生的高血压有显著的关联.
- 没有发现与高血压发展相关的HIV特异性因素.
结论:
- 在得到良好治疗的PWH中,高血压的发病率与一般人群相比较.
- 传统的风险因素,特别是年龄和脂肪组织分布,与PWH的高血压有关.
- 预防策略应侧重于生活方式的改变和体重管理,而不是针对艾滋病毒的特定因素.
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