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Updated: Jul 28, 2025

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为染色体重塑复合体设计I/IV类基基向降解剂的设计

Huda Zahid1, Jeff P Costello1, Yao Li2

  • 1Department of Chemistry, University of Minnesota, 207 Pleasant St. SE, Minneapolis, Minnesota 55455, United States.

ACS chemical biology
|June 1, 2023
PubMed
概括

新的向蛋白质降解剂旨在向非BET基,在癌症中至关重要. 基于pyrimidine的分子成功降解了CECR2,这是一个关键的表观遗传标,对未来的癌症治疗有希望.

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