关于脂肪组织和癌症的最新消息
Kristy A Brown1,2, Philipp E Scherer3
1Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Endocrine reviews
|June 1, 2023
概括
肥胖,或增加脂肪,通过改变脂肪组织功能和促进代谢功能障碍,促进癌症的发展和进展. 这一综述更新了关于脂肪组织如何影响癌症发病和生长的文献.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 脂肪组织,最大的内分泌器官,显著影响能量恒温.
- 增加脂肪与13种癌症,代谢功能障碍和胰岛素抵抗有关.
- 脂肪组织与器官交叉,影响乳腺癌,结肠癌和子宫内膜癌等癌症的发展,生长和进展.
研究的目的:
- 提供有关脂肪组织在癌症发病和进展中的作用的文献的最新审查.
- 要突出肥胖相关的脂肪组织功能障碍促进癌症的机制.
- 总结代谢变化和脂肪和瘤细胞之间的交叉声对癌症发展的影响.
主要方法:
- 关于研究脂肪组织,肥胖和癌症之间的联系的文献综述.
- 分析参与脂肪组织重塑的分子和细胞机制及其对癌症的影响.
- 在肥胖-癌症轴上的荷尔蒙,代谢和炎症调解者的证据综合.
主要成果:
- 肥胖引起的代谢功能障碍,包括胰岛素抵抗,促进癌症的生长.
- 脂肪组织分泌促进癌症的因素 (例如,瘦素,内分泌素),同时失去保护性因素 (例如,脂肪素).
- 结构性脂肪组织重塑 (纤维化,血管生成中断) 和营养供应 (脂肪酸,乳酸) 支持瘤进展.
结论:
- 脂肪组织在各种癌症的发病和进展中起着至关重要的作用.
- 脂肪组织中由肥胖驱动的改变创造了一个亲瘤的微环境.
- 了解这些复杂的相互作用对于开发向癌症疗法至关重要.
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