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在非老年人和患有密码性中风的老年患者中,专利性卵巢孔关闭:基于医院的队列研究
Po-Lin Chen1,2,3, Chi-Sheng Wang1, Jin-An Huang1,3,4
1Division of Neurology, Taichung Veterans General Hospital, Neurological Institute, Taichung, Taiwan.
Frontiers in neurology
|June 1, 2023
概括
专利卵孔 (PFO) 关闭减少了密码性中风患者的复发性中风和死亡率. 经过PFO关闭的老年患者表现出改善的功能结果,这表明在选择的老年人中考虑它.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医疗器械 医疗器械
背景情况:
- 圆孔 (PFO) 是一种常见的心脏异常.
- 在患有密码性中风 (CS) 的老年患者中PFO关闭的疗效尚不清楚.
研究的目的:
- 调查PFO关闭在非老年和老年CS患者中的有效性和安全性.
- 为了比较PFO关闭和仅仅医疗管理之间的结果.
主要方法:
- 预期招募CS/TIA和PFO的患者 (≥18岁).
- 分类为PFO关闭 (PFOC) 和医疗治疗 (非PFOC) 组.
- 主要结局:复发性脑缺血事件和全因死亡率的组合;次要结局:修改了180天的排名表 (mRS).
主要成果:
- 关闭PFO显著降低了总队列中的主要结果 (6.2%对17.1%,HR=0.35,p=0.043).
- 经过PFO关闭的老年患者表现出主要结局的数值较低的风险 (HR=0.26,p=0.051) 和更好的功能结局 (较低的中位数mRS,p=0.002).
- 在不同组和年龄类别之间,安全结果是相似的.
结论:
- 关闭PFO与PFO和CS患者中复发事件的风险降低有关.
- 患有PFO关闭的老年患者经历了更好的功能结果.
- 对于某些患有PFO的老年患者来说,PFO关闭可能是一个可行的选择.
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