在生与死之间:大脑的黄昏区域
1Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital de la Pitié-Salpêtriére, Paris, France.
Frontiers in neuroscience
|June 1, 2023
概括
死亡是一个复杂的过程,涉及大脑活动的变化,而不仅仅是一个单一的事件. 成功的复苏可以扭转这些变化,标志着新的"复苏浪潮".
科学领域:
- 神经科学是一个神经科学.
- 生理学 生理学 生理学
- 医疗法 法律 医疗法
背景情况:
- 临床死亡在法律上被定义为不可逆转地停止大脑活动.
- 心肺衰竭会导致复杂的,依赖时间的神经元变化,通过复苏可逆.
- 目前基于事件的死亡模型在神经生理学上是不充分的.
研究的目的:
- 为了审查死亡和复苏期间的大脑活动的变化.
- 提出一种新的死亡和复苏混合 (事件过程) 模型.
- 将垂死的大脑阶段整合到不断下降的大脑活动中.
主要方法:
- 审查实验和临床证据对死亡和复苏期间的大脑活动.
- 对无氧依赖性脑缺陷及其序列的分析.
- 识别生物标志物,如"死亡浪潮"和"复活浪潮".
主要成果:
- 死亡涉及连续的大脑变化:EEG变化,同电状态,失去意识,电阻增加",死亡波" (终端扩散脱极化) 和终端同电状态.
- 重生可以启动一个反射序列:神经元再极化和电活动的重新出现.
- 一个"复苏浪潮"标志着神经元在重新氧化过程中恢复电气性质.
结论:
- 死亡过程是大脑活动下降的连续过程,而不是突然发生的事件.
- 拟议的混合模型包含"大脑黄昏区域"和特征性皮质波.
- 可以确定死亡和复苏的实时生物标志物.
相关概念视频
Kubler Ross's Stages of Dying
139
Elisabeth Kübler-Ross significantly advanced psychology's understanding of the process of dying with her influential book, On Death and Dying (1969). She focused on studying terminally ill individuals and outlined five stages commonly experienced when coping with death: denial, anger, bargaining, depression, and acceptance.
In denial, individuals reject the reality of their condition, often thinking, "This isn't true; I feel fine," as a way to protect themselves from...
In denial, individuals reject the reality of their condition, often thinking, "This isn't true; I feel fine," as a way to protect themselves from...
139
Brain Waves
1.7K
Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:
1.7K
High-Level and Low-Level Awareness
296
Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...
296
Stages of Sleep
395
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
395
Subconsciousness and No Awareness
276
The concept of subconscious awareness refers to the processing of information below the level of conscious thought, which significantly influences both behaviors and decisions. It is also known as waking subconscious awareness. This complex level of cognition operates without the direct awareness of the individual, facilitating rapid and simultaneous handling of multiple information streams.
An illustrative example of subconscious processing is its role in problem-solving. Often, individuals...
An illustrative example of subconscious processing is its role in problem-solving. Often, individuals...
276
Lucid Dreaming
182
Lucid dreaming is a unique state of consciousness where an individual realizes they are dreaming while still in the dream. This awareness allows them to manipulate their dream environment consciously. Researchers like Stephen LaBerge have significantly contributed to the understanding of lucid dreams, highlighting that during these dreams, certain areas of the brain, such as the prefrontal cortex, that involve self-awareness and thought evaluation show increased activity.
Studies have shown...
Studies have shown...
182


