竞争性风险名录的临床特征和前列腺癌特异性死亡率在第二种前列腺癌中
Chaojie Xu1, Dongchen Pei1, Yi Liu1
1Department of Urology, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Frontiers in oncology
|June 1, 2023
概括
这项研究确定了第二次原发性前列腺癌 (spPCa) 预后的关键风险因素. 开发了一种预测性名谱,以估计spPCa患者的生存结果.
科学领域:
- 在瘤学瘤学.
- 癌症流行病学 癌症流行病学
背景情况:
- 随着癌症诊断和治疗的进步,第二次原发性恶性瘤 (SPM) 越来越被认可.
- 第二次原发性前列腺癌 (spPCa) 是SPM的一个重要亚型,需要进一步了解.
研究的目的:
- 在患有spPCa.的患者中确定前列腺癌特异性死亡率 (PCSM) 的风险因素.
- 开发和验证spPCa.中PCSM的预测名录.
主要方法:
- 从SEER数据库 (2004-2015) 中对3322名spPCa患者进行了回顾性分析.
- 用多变量竞争性风险回归来确定PCSM的风险因素.
- 使用C指数,校准曲线和决策曲线分析 (DCA) 构建和验证了一个名图.
主要成果:
- 常见的SPM部位包括泌尿,消化和皮肤系统.
- 鉴定了spPCa预后的风险因素:种族,TNM阶段,格里森得分,手术和放射治疗.
- 诺米图表表现出良好的预测性能,在训练 (0.856) 和验证 (0.905) 集中具有高的C指数.
结论:
- 确定了四个风险因素,这些风险因素显著影响了spPCa的预后.
- 经过验证的竞争性风险名图可以准确地预测spPCa患者的3年,5年和10年的PCSM.
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