年轻成年人自身主导性多囊性病
Víctor Martínez1, Mónica Furlano2, Laia Sans3
1Nephrology Department, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Clinical kidney journal
|June 1, 2023
概括
患有自体主导多囊性病 (ADPKD) 的年轻人表现出显著的发病率,特别是高血压,这种发病率比一般ADPKD人群更早. 早期评估对于危险年轻人及时诊断和治疗高血压至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 遗传学 遗传学 是一个
- 内部医学 内部医学
背景情况:
- 自体主导多囊性病 (ADPKD) 通常在成年期表现出来,但在儿科病例中可能呈现出高发病率.
- 尽管疾病负担很大,但年轻人的临床表现往往被忽视.
研究的目的:
- 分析年龄在18-30岁的年轻成年人ADPKD的临床特征.
- 在这个特定的人口群体中调查高血压的患病率和预测因素.
主要方法:
- 来自西班牙ADPKD注册表 (REPQRAD) 的346名年轻成年人 (18-30岁) 的回顾性分析.
- 评估家族病史,高血压,白蛋白尿,eGFR和成像数据.
- 对儿科ADPKD队列和年轻成人ADPKD高血压研究的文献综述.
主要成果:
- 在年轻人中,高血压诊断的平均年龄为21.15岁,比一般的ADPKD人口 (37.6岁) 早得多.
- 在年轻成年人中,高血压的患病率为28.03%,随着年龄的增长而增加 (在18-24岁的人群中为16.8%,在25-30岁的人群中为36.8%).
- 在多变量分析中,血和长被确定为高血压的独立预测因子 (AUC 0.75).
结论:
- 患有ADPKD的年轻人经历了相当大的发病率,包括早期出现的高血压.
- 早期和彻底评估年轻成年人患ADPKD风险对于早期发现和管理高血压至关重要.
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