相关实验视频
Updated: Jul 28, 2025

08:53
Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
Published on: August 31, 2016
15.3K
在异性干细胞移植候选人中评估功能储备的理由:试点研究
Nicoletta Mancianti1, Andrea Guarnieri1, Mariapia Lenoci2
1Dipartimento di Emergenza-Urgenza e dei Trapianti, UOC Nefrologia, Dialisi e Trapianti, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Clinical kidney journal
|June 1, 2023
概括
功能储备 (RFR) 可以预测血造干细胞移植 (HSCT) 后的急性损伤 (AKI). 移植前的RFR超过20%与AKI后的功能完全恢复有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植医学 移植医学
- 脏生理学 脏生理学
背景情况:
- 造血干细胞移植 (HSCT) 存在急性损伤 (AKI) 的风险.
- 基于功能储备 (RFR) 的分层患者可以预测AKI及其结果.
- 鉴定后HSCT AKI 的风险因素对于患者管理至关重要.
研究的目的:
- 评估RFR在HSCT100天内分层AKI风险的能力.
- 为了确定RFR对功能恢复或慢性病发作的预测值.
- 在HSCT后确定AKI的临床和实验室风险因素.
主要方法:
- 一项前性观察性研究,涉及48名接受异构HSCT的患者,其基底膜过率 (bGFR) 正常.
- 功能储备测试 (RFR-T) 使用口服蛋白质负荷应激测试,在HSCT前15天进行.
- 与RFR-T一起进行多参数评估.
主要成果:
- 在48名患者中,有29名 (60%) 患有AKI.
- 较低估计的GFR (eGFR) ≤100mL/min/1.73m2与AKI风险显著相关 (P=.001).
- 在AKI+患者 (28%) 和AKI-患者 (40%) 中,RFR-T较低,尽管在统计学上不显著.
- 在HSCT前的RFR>20%与AKI后的完整功能恢复相关 (P=.041).
结论:
- RFR可以识别亚临床功能障碍,预测AKI后恢复.
- 在HSCT前的eGFR和RFR与AKI风险和恢复有关.
- 利用eGFR和RFR可以指导移植管理和早期脏干预.
相关概念视频
Kidney Transplant I: Introduction
29
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
29
Bone Marrow Sampling and Transplants
364
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
364
Factors Affecting Renal Clearance: Renal Impairment
125
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
125
Kidney Transplant II: Surgical Procedure
37
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
37

