TLR8和RIG-I类受体之间的交叉声会增强抗病毒免疫反应
Killian E Vlaming1,2, Kelly van Wijnbergen1,2, Tanja M Kaptein1,2
1Department of Experimental Immunology, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Frontiers in medicine
|June 1, 2023
概括
同时刺激托尔类受体 (TLR) 和RIG-I类受体 (RLR) 激素增强抗病毒免疫力. 这种组合增强IL-12和I型干扰素 (IFN) 反应,这表明HIV潜伏逆转和免疫清除的有效策略.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 收费类受体 (TLR) 激活剂正在被探索用于艾滋病毒治疗,针对HIV感染者 (PLWH) 的潜伏逆转和免疫调节.
- 调查与RIG-I类似受体 (RLR) 激动剂同时刺激TLR激动剂对抗病毒免疫的协同效应至关重要.
研究的目的:
- 为了确定TLR7/8激动剂与RLR激动剂的同时刺激是否增强抗病毒免疫反应.
- 评估这种共同刺激对细胞因子产生和干扰素刺激基因表达 (ISG) 的影响.
主要方法:
- 周围血液单核细胞 (PBMC) 和单细胞衍生的树突细胞 (DC) 用TLR和RLR激动剂进行治疗.
- 评估了先天性和适应性免疫反应,包括成熟标志物,细胞因子概况和ISG表达.
主要成果:
- TLR7和TLR8激动剂在DC和PBMC中都诱导了促炎细胞因子;TLR8激动剂显示出更大的效力.
- 与TLR8激动剂和RLR激动剂polyI:C的同时刺激在PBMC中显著提高了IL-12p70水平.
- TLR8和RLR激动剂之间的交叉声诱导了强大的I型干扰素 (IFN) 反应,比单个激动剂更有效地调节抗病毒ISG.
结论:
- TLR和RLR交叉产生强大的抗病毒免疫力,通过增加IL-12和I型IFN反应来证明.
- 同时刺激TLRs和RLRs是重新激活潜伏HIV储存和通过增强抗病毒免疫力消除感染细胞的有希望的策略.
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