接种COVID-19和流感疫苗的时间和序列 (TACTIC):是一项单盲,安慰剂控制的随机临床试验
Elisabeth A Dulfer1,2, Büsra Geckin1,2, Esther J M Taks1,2
1Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
The Lancet regional health. Europe
|June 1, 2023
概括
同时接种COVID-19和流感疫苗是安全的,但可能会略微减少抗体反应. 需要进一步的研究来确认对抗SARS-CoV-2和流感的保护的潜在影响.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 针对COVID-19和流感的mRNA疫苗至关重要,特别是在脆弱人群中.
- 有关这些疫苗之间潜在的免疫干扰存在担忧.
研究的目的:
- 为了研究mRNA COVID-19增强剂和四价流感疫苗之间的免疫干扰.
- 为了评估同时使用疫苗的安全性和免疫性.
主要方法:
- 在TACTIC随机临床试验中,参与者年龄在60岁以上.
- 参与者接种了连续性,并发性或仅仅是COVID-19的强剂疫苗.
- 主要结局:IgG抗体对SARS-CoV-2尖端蛋白的几何平均度.
主要成果:
- 与基准组相比,同时接种疫苗不符合非劣质标准.
- 同时治疗组的抗体中和能力明显较低.
- 两组之间报告的副作用没有显著差异.
结论:
- 同时接种COVID-19和流感疫苗是安全的.
- 随着同时使用,定量和功能性抗体反应略低.
- 与同时接种疫苗减少COVID-19保护的潜力需要进一步调查.
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