与巨细胞和干扰素反应相关的失调的早期转录特征与COVID-19严重程度有关
Rachel MacCann1,2,3, Alejandro Abner Garcia Leon3, Gabriel Gonzalez3,4,5
1School of Medicine, University College Dublin, Dublin, Ireland.
Frontiers in immunology
|June 1, 2023
概括
COVID-19患者的早期免疫反应表明,与干扰素活性升高相结合的乳腺细胞反应减弱预测了严重的疾病. 这表明免疫失调可能导致,而不仅仅是严重的冠状病毒疾病2019 (COVID-19) 的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 遗传学 是一个遗传学.
背景情况:
- 失调的免疫反应与严重的2019年冠状病毒病 (COVID-19) 有关.
- 了解早期宿主免疫基因表达可能会预测临床进展到严重疾病.
研究的目的:
- 确定早期宿主免疫相关基因表达是否可以预测临床进展到严重的COVID-19.
- 分析与COVID-19严重程度相关的免疫基因表达和细胞因子概况.
主要方法:
- 从SARS-CoV-2阳性和阴性个体的外围血液单核细胞中分析了579个免疫基因的表达.
- 测量了I型,II型和III型干扰素 (IFN) 和10种额外的细胞因子的血水平.
主要成果:
- 在症状出现5天内确定了19个显著放松调节的基因.
- 在轻度和中度/重度SARS-CoV-2组中发现了I型干扰素信号传导和促炎细胞因子基因的上调.
- 在中度/重度COVID-19中观察到FCER1 (乳腺细胞激活) 的下调,以及IFN,IL-10和IL-6的升高,表明乳腺细胞反应缺陷和IFN过度反应.
结论:
- 早期宿主免疫反应,特别是巨细胞激活缺陷与干扰素过度响应相结合,与更严重的COVID-19结果相关.
- 这些发现表明,早期免疫失调可能是严重的COVID-19的原因,而不是后果.
- 对这种途径的进一步研究可以为脆弱个体的治疗提供信息.
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