近视和眼部生物识别作为原发性开放角眼的危险因素的角色中的种族和种族差异
Sarah Zhou1, Bruce Burkemper2, Anmol A Pardeshi2
1Keck School of Medicine at the University of Southern California, Los Angeles, California, United States.
Investigative ophthalmology & visual science
|June 1, 2023
概括
折射误差和轴长度是跨种族原发性开角玻璃眼 (POAG) 的关键风险因素. 在某些群体中近视频率更高可能会增加他们在全球范围内不成比例地患POAG的风险.
科学领域:
- 眼科医生 眼科 眼科
- 流行病学 流行病学
- 遗传学 遗传学 是一个
背景情况:
- 主要开角青光眼 (POAG) 是全球不可逆转失明的主要原因.
- 折射误差 (RE) 和眼部生物识别,如轴长 (AL),是POAG.确定的风险因素.
- 了解这些风险因素在不同种族和种族群体之间如何变化对于有针对性的预防和管理策略至关重要.
研究的目的:
- 调查折射误差和眼部生物识别的差异性作用,作为多种种族和民族群体中原发性开角玻璃眼 (POAG) 的风险因素.
- 通过种族和种族来评估POAG及其风险因素之间的关系的效果修改.
主要方法:
- 来自洛杉矶拉丁裔眼睛研究 (LALES) 和华裔美国人眼睛研究 (CHES) 的基于人口的数据的回顾性分析.
- 包括7601名50岁及以上的法基参与者.
- 应用多变量后勤回归和相互作用术语分析来评估POAG,RE,AL和种族/种族之间的关系.
主要成果:
- 拉丁裔美国人 (6.0%) 的POAG患病率高于华裔美国人 (4.0%).
- 对POAG的显著风险因素包括拉丁裔种族,近视 (RE) 和较长的轴长度 (AL).
- 轴长与POAG的关联比高近视更强;对于RE或AL与POAG的关联,没有观察到任何显著的种族/民族修饰.
结论:
- 虽然与近视RE和较长AL相关的POAG风险在拉丁裔和华裔美国人之间是可比的,但华裔美国人的更高近视患病率部分抵消了整体POAG患病率的差异.
- 全球近视流行可能导致POAG病例在种族/族群中不成比例增加,近视发病率较高.
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