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Updated: Jul 28, 2025

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晶体结构和实验室进化阿尔德海德减少酶的运动研究解释了其新基质特异性的戏剧性转变

Shruthi Sridhar1, Alberto Zavarise1, Tiila Riikka Kiema2

  • 1Department of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.

IUCrJ
|June 1, 2023
PubMed
概括

定向进化创造了一个高度活跃的大肠杆菌FucO酶变体 (DA1472) 用于重的基板. 结构和功能研究解释了它对乙的活性增加了9000倍,增强了生物催化潜力.

关键词:
这就是FucOO.阿尔德海德减少酶的作用指导进化是指导进化的.酶的功能 酶的功能酶的机制是酶的机制.基质选择性 基质选择性

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