SARS-CoV-2和神经系统:当前的观点.
Amrita Pattanaik1, Sushma Bhandarkar B2, Lonika Lodha3
1Manipal Institute of Virology, Manipal Academy of Higher Education (MAHE), PIN-576104, Manipal, Karnataka, India. amrita.pattanaik@manipal.edu.
严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染可能导致神经功能障碍. 本综述检查了与COVID-19相关的神经系统疾病的病理生理学和表现.
科学领域:
- 神经学 神经学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- SARS-CoV-2 感染越来越多地与成人和儿童的神经系统并发症有关.
- 了解这些神经表现的病理生理学对于有效管理至关重要.
研究的目的:
- 审查最近关于SARS-CoV-2感染与神经系统疾病之间的关联的文献.
- 讨论潜在的直接和间接机制 COVID-19 相关的神经障碍的潜在直接和间接机制.
主要方法:
- 关于COVID-19和神经病学的最新出版物的文献综述.
- 对病毒病理生理学和免疫反应的分析.
- 根据疾病阶段 (急性和后急性) 分类神经症状.
主要成果:
- 神经功能损害可以发生在SARS-CoV-2感染的急性和后急性阶段.
- 潜在的原因包括直接的病毒入侵大脑和间接的免疫中介反应.
- 与COVID-19相关的广泛的神经系统疾病已被报告.
结论:
- COVID-19对发展神经系统疾病具有重大风险.
- 需要进一步的研究才能充分阐明SARS-CoV-2对神经系统的机制和长期影响.
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