对极端年龄的炎症性肠病表型进行前性研究,并与成人进行比较
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Nikhil Bhangale1, Devendra Desai2, Philip Abraham1
1Division of Gastroenterology, P D Hinduja Hospital, Veer Savarkar Marg, Mahim, Mumbai, 400 016, India.
概括
儿科和老年炎症性肠病 (IBD) 呈现出不同的特征. 儿科IBD表现出更具侵略性的表型,而老年IBD通常不那么严重,影响治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 炎症性肠道疾病研究研究
背景情况:
- 儿科和老年人群的炎症性肠病 (IBD) 尚未得到充分研究,回顾性数据有限.
- 儿科IBD通常表现出更具侵略性的表型,需要密集治疗.
- 老年IBD可能呈现出不那么积极的疾病模式.
研究的目的:
- 为了前性地比较儿科,成人和老年IBD患者的疾病特征.
- 为了确定疾病表型,行为和治疗要求的年龄特定差异.
主要方法:
- 这是一项针对266名IBD患者的前性单中心队列研究.
- 患者被分为儿科 (≤16岁),成人 (17-59岁) 和老年人 (≥60岁) 组.
- 收集的数据包括疾病特征,行为,肠外表现和至少六个月的随访期间的治疗.
主要成果:
- 儿科性结肠炎 (UC) 患者更经常患有胰腺炎 (p=0.018).
- 老年UC患者表现出更惰的行为和更少的肠外表现 (p=0.005).
- 儿科克罗恩氏病 (CD) 患者患有更多结肠病 (p=0.02),而老年CD患者患有更多的阴茎病 (p=0.04).
- 儿科CD患者需要更频繁的生物药物 (p=0.005),而老年CD患者需要更少的类固醇,生物药物,免疫抑制剂和手术 (p<0.05).
结论:
- 在IBD的表现和治疗中存在与年龄相关的显著差异.
- 儿科CD显示了结肠疾病的倾向,老年CD显示了大肠疾病的倾向,与一些西方文学相反.
- 老年CD患者的近部疾病发生频率较低,并且需要不那么密集的医疗和手术治疗.
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