静脉注射免疫球蛋白在异常性炎症性肌肉病:临床使用实用指南
Prateek C Gandiga1, Daniela Ghetie2, Elizabeth Anderson3
1Division of Rheumatology, Emory University, Atlanta, GA, USA. prateek.gandiga@emory.edu.
Current rheumatology reports
|June 1, 2023
概括
静脉注射免疫球蛋白 (IVIG) 是一种安全有效的治疗异常性炎症性肌肉病 (IIM),解决肌肉和皮肤症状. 最近的研究证实了它的有效性,为管理这些复杂的自身免疫性疾病提供了有价值的选择.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 异形性炎症性肌肉病变 (IIM) 是一种影响肌肉和皮肤的自身免疫性疾病,导致显著的发病率.
- 对IIM的最佳治疗策略仍然不确定,需要探索有效的治疗选择.
研究的目的:
- 为使用静脉注射免疫球蛋白 (IVIG) 和皮下免疫球蛋白 (SCIG) 治疗IIM提供实用指南.
- 总结一下IVIG在特殊情况下使用的考虑因素,如消化不良,ILD,皮质结核病和怀孕.
- 讨论IVIG安全性,配方和IIM管理中的相关成本.
主要方法:
- 审查最近的文献和临床经验.
- 专注于IVIG/SCIG在各种IIM亚型 (DM,PM,IMNM,IBM) 的实际应用.
- 包括特殊情况和安全/成本考虑.
主要成果:
- IVIG已经在IIM中证明了安全性和有效性,并得到了最近的高影响性研究的支持,包括DM的III期试验.
- 在各种IIM类型中,IVIG对肌肉和肌肉外表现都有效.
- 可以使用IVIG作为一线,类固醇节约剂或作为辅助疗法,根据临床情景量身定制.
结论:
- IVIG是一种耐受性良好的治疗方法,对IIM来说具有良好的安全性.
- 可访问性和成本仍然是IVIG广泛使用的障碍.
- 最近的证据支持IVIG作为IIM管理中的一个有价值的治疗选择.
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