一个随机对照试验对比的临床结果在没有并发症的SAM管理和没有抗生素
Yashwant Kumar Rao1, Vaishnavi Baranwal2, Tanu Midha3
1Department of Pediatrics, GSVM Medical College, Kanpur, Uttar Pradesh, India. ykraoneo@yahoo.co.in.
Indian journal of pediatrics
|June 1, 2023
概括
在儿童严重急性营养不良 (SAM) 管理中添加抗生素并没有显著改善临床或人体测量结果. 这项随机对照试验在接受抗生素和不接受抗生素的儿童之间没有发现差异.
科学领域:
- 儿科 儿科 儿科
- 营养科学 营养科学
- 传染性疾病 传染性疾病
背景情况:
- 严重急性营养不良 (SAM) 是儿童的关键全球健康问题.
- 基于社区的SAM管理旨在提高可访问性和结果.
- 抗生素在无并发性SAM中的作用需要进一步的临床评估.
研究的目的:
- 评估抗生素在非复杂严重急性营养不良 (SAM) 的社区管理中的临床疗效.
- 为了比较SAM儿童与抗生素治疗和没有抗生素治疗的人类测量和临床结果.
主要方法:
- 一项随机对照试验,涉及100名年龄在6~59个月的儿童,在坎普尔农村接受无并发性SAM治疗.
- 儿童被随机分为两组:一组接受一周的抗生素疗程,一组控制组没有接受抗生素.
- 人口,临床和人体测量数据是在入学和两周后期收集的.
主要成果:
- 在两周的随访中,抗生素和对照组之间在人体参数 (体重与年龄,身高与年龄,体重与身高的Z-分数) 中没有发现显著差异.
- 随访时体重/身高Z-分数在干预组为-1.29±0.84,在对照组为-1.45±0.93 (p=0.436).
- 这些群体之间的社会经济地位和性别分布是可比的.
结论:
- 抗生素的使用似乎不会显著改变在社区层面管理的无并发性SAM儿童的临床或人体测量改善.
- 在不需要常规抗生素使用的情况下,可以遵循不复杂的SAM的标准管理协议.
- 进一步的研究可能会探索特定的子组或并发症,其中抗生素可能是有益的.
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