在糖尿病患者中发生的系统性不良事件 糖尿病患者接受了内抗血管内皮生长因子注射的治疗
Sidra Zafar1, Annette Walder2, Salim Virani2,3
1Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
JAMA ophthalmology
|June 1, 2023
概括
针对糖尿病视网膜病变 (DR) 的静脉内抗血管内皮生长因子 (VEGF) 注射与糖尿病患者的全身不良事件增加有关. 这一发现凸显了DR处理中潜在的安全问题.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 抗血管内皮生长因子 (VEGF) 药物是糖尿病视网膜病变 (DR) 的标准治疗方法.
- 对抗VEGF药物的系统安全性数据,特别是对高危糖尿病患者的系统安全性数据,需要进一步调查.
研究的目的:
- 在被诊断为糖尿病的患者中评估内抗VEGF药物的系统安全性.
- 确定抗VEGF注射和发生的系统性不良事件之间的关联.
主要方法:
- 使用美国退伍军人卫生事务公司数据仓库进行了回顾性,纵向的基于人口的分析.
- 包括2011-2012年18岁以上的2型糖尿病患者,追踪了2013-2017年系统性不良事件数据.
- 在接受和不接受静脉内抗VEGF注射的患者之间,系统性不良事件率的比较.
主要成果:
- 分析了超过170万名2型糖尿病患者;0.8%接受了抗VEGF注射.
- 与未注射患者 (18.4%) 相比,接受抗VEGF注射的患者的系统性不良事件的累计5年发生率 (37.0%) 显著更高.
- 抗VEGF注射独立地与80%的系统性不良事件增加的可能性相关 (OR,1.8;95% CI,1.7-1.9).
结论:
- 内抗VEGF注射与糖尿病患者全身不良事件的风险增加独立相关.
- 这些发现表明,在为糖尿病视网膜病变开处方抗VEGF疗法时,需要仔细考虑系统安全性.
- 需要进一步的研究来阐明这些系统性风险的机制和临床影响.
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