区域大脑缩和大脑衰老的模式在中年和老年成人1型糖尿病
Mohamad Habes1,2, Alan M Jacobson3, Barbara H Braffett4
1Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio, San Antonio.
JAMA network open
|June 1, 2023
概括
1型糖尿病 (T1D) 与加速的大脑衰老有关,大约比对照组年龄大六年,但没有早期阿尔茨海默病 (AD) 症状. 这种大脑衰老与T1D患者的认知功能下降相关.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
背景情况:
- 1型糖尿病 (T1D) 可能会影响大脑结构并加速衰老,但对神经影像标志物和阿尔茨海默病 (AD) 的数据有限.
- 了解这些变化对于早期检测和管理T1D潜在的神经并发症至关重要.
研究的目的:
- 通过神经成像评估DCCT/EDIC研究中T1D参与者的大脑年龄和AD类缩.
- 确定受T1D影响最大的大脑区域及其与认知功能和大脑衰老的关联.
主要方法:
- 一项使用DCCT/EDIC研究数据的队列研究,包括416名T1D参与者和99名对照.
- 磁共振成像 (MRI) 和机器学习被用来计算大脑年龄和AD类缩.
- 认知评估包括口头流利,数字符号替换,步道制作B,槽板和即时记忆测试.
主要成果:
- T1D参与者表现出显著更高的大脑年龄 (约. 6岁以上) 与对照组 (P < .001) 相比.
- 在T1D参与者和对照人群之间,没有发现与AD相关的区域性缩的显著差异.
- 在T1D患者中,大脑年龄较大与心理运动和心理效率较低有关 (P < .001).
结论:
- 患有T1D的个体显示大脑老化增加的证据,但没有早期AD相关的神经退行.
- 在T1D中,加速的大脑衰老与认知能力下降有关.
- 尽管T1D持续时间长,但这些大脑变化是适度的.
相关概念视频
Alzheimer's Disease: Overview
539
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
539
Psychoneuroimmunology: Diabetes and Cancer
50
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
50
Diabetes: Symptoms, Diagnosis, and Complications
606
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
606


