全球,种族中立的参考方程和肺功能测试解释
Alexander T Moffett1,2,3, Cole Bowerman4,5, Sanja Stanojevic4
1Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia.
JAMA network open
|June 1, 2023
概括
在肺功能测试 (PFT) 中使用种族中立方程显著增加了黑人呼吸系统损伤的识别和严重程度. 这一转变凸显了对诊断和治疗肺部疾病的潜在影响.
科学领域:
- 肺部医学 肺部医学
- 健康 公平 卫生 公平
- 医学诊断 医学诊断 医学诊断
背景情况:
- 肺功能测试 (PFT) 的解释传统上包括种族和种族,这种做法缺乏生物学理由,并可能加剧健康差异.
- 最近的进展导致了PFT解释的种族中立参考方程的开发.
研究的目的:
- 用新开发的种族中立参考方程与现有的种族特定方程比较PFT解释.
- 评估种族中立方程对肺功能障碍的患病率和严重性的影响.
主要方法:
- 一项横截面研究分析了2010年至2020年期间2722名黑人和5709名白人的PFT.
- 从种族中立的全球肺功能倡议 (GLI) 方程的解释与GLI 2012年种族特定方程的解释进行了比较.
- 主要结局包括阻塞性,限制性和非特异性肺功能障碍的百分比差异;次要结局评估严重程度差异.
主要成果:
- 在黑人个人中,种族中立方程增加了限制患病率 (26.8%至37.5%) 和非特异性损伤 (3.2%至6.5%),阻塞没有显著变化.
- 在白人个体中,种族中立方程降低了限制患病率 (22.6%至18.0%) 和非特异性障碍 (8.7%至4.0%),阻塞没有显著变化.
- 种族中性方程增加了22.8%的黑人个体的损伤严重程度,并减少了19.3%的白人个体.
结论:
- 采用种族中立的参考方程来解释PFT导致黑人个体中发现的呼吸系统障碍及其严重程度的显著增加.
- 需要进一步的研究才能充分理解这些种族中立方程对诊断,患者转诊和治疗策略的临床影响.
相关概念视频
Pulmonary Function Tests
383
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
383
Respiratory Capacities
857
Respiratory capacities are crucial indicators of lung function, representing the maximum amount of air an individual's respiratory system can handle during various breathing phases.
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...
857
Respiratory Volumes and Capacities I
1.1K
Assessing the respiratory rate and rhythm for a complete minute is crucial for evaluating the breathing pattern. Even a minor increase in the patient's average respiratory rate, by as little as three to five breaths per minute, is an early and vital indicator of respiratory distress. Patients with a respiratory rate exceeding twenty-four breaths per minute require close monitoring to determine the physiological alterations. This careful observation is essential for prompt recognition and...
1.1K
Respiratory Volumes and Capacities
2.2K
The respiratory system is responsible for the intake of oxygen and the expulsion of carbon dioxide from the body. Respiratory volumes describe the volume of air in the lungs at different phases of the respiratory cycle. Tidal volume is the air breathed in and out during normal, quiet breathing. Inspiratory reserve volume is the air that can be forcefully inspired beyond the tidal volume. In contrast, expiratory reserve volume refers to the air that can be expelled from the lungs after a normal...
2.2K
Respiratory Volumes
1.6K
Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
1.6K
Lung Capacity
51.0K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
51.0K


