系统化疗在患有低度粘性尾腺癌的患者中的有效性:一个随机交叉试验
John Paul Shen1, Abdelrahman M Yousef1, Fadl A Zeineddine2
1Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston.
JAMA network open
|June 1, 2023
概括
基于烯胺的化疗对不可手术的低度粘膜尾腺癌患者没有益处. 治疗没有显示出客观反应或改善整体存活率,并恶化了生活质量.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床试验 临床试验
背景情况:
- 尾腺癌很罕见,治疗决策指导的高质量数据有限.
- 未来的试验具有挑战性,需要进一步的临床前和临床研究.
研究的目的:
- 为了前性地评估基于烯胺的全身化疗的有效性.
- 评估化疗对不可手术的低度粘膜尾腺癌的影响.
主要方法:
- 一个开放标签,随机交叉试验 (NCT01946854) 涉及24名患者.
- 患者接受了6个月的观察,然后进行化疗,或初始化疗,然后进行观察.
- 主要终点:瘤生长的差异;次要终点:生活质量,反应率,整体存活率.
主要成果:
- 化疗和观察期间之间瘤生长没有显著差异 (8.4%对4.0%).
- 没有观察到客观反应,77.8%的病情稳定,22.2%的病情进展.
- 总体生存率没有显著差异;化疗与更严重的疲劳,神经病变和财务困难有关.
结论:
- 基于甲的化疗对这种患者群体没有临床益处.
- 延迟化疗没有影响整体存活率.
- 为了有效治疗尾腺癌,需要进一步的研究.
更多相关视频
04:22Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis
Published on: March 3, 2023
479
09:48An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
8.2K
相关概念视频
01:29Appendicitis-II: Diagnostic Studies and Management
104
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
104
01:22Appendicitis-I: Introduction
290
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
290