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相关概念视频

False Memories01:18

False Memories

120
False memories represent a cognitive distortion in which individuals recall events that did not happen, or remember them in an altered form. This phenomenon highlights the brain's constructive nature in processing and recalling memories, emphasizing that memory is not a perfect representation of past events but rather a dynamic reconstruction influenced by various factors.
One primary source of false memories is misattribution, where individuals incorrectly associate external information...
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Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Confirmation Biases01:31

Confirmation Biases

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The confirmation bias is the tendency to focus on information that confirms our existing beliefs and ignore information that is inconsistent with our expectations. For example, if you think that your professor is not very nice, you notice all of the instances of rude behavior exhibited by the professor while ignoring the countless pleasant interactions he is involved in on a daily basis. Have you ever fallen prey to the confirmation bias, either as the source or target of such bias?
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Mismatch Repair01:36

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Overview
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Hindsight Biases01:12

Hindsight Biases

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Hindsight bias leads you to believe that the event you just experienced was predictable, even though it really wasn’t. In other words, you knew all along that things would turn out the way they did. Can you relate this to the phrase "Hindsight is 20/20" now? 
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Difference from Background: Limit of Detection01:05

Difference from Background: Limit of Detection

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The limit of detection (LOD) is the smallest amount of analyte that can be distinguished from the background noise. The LOD value corresponds to the concentration at which the analyte signal is three times larger than the standard deviation of the blank signal. Below this value, the analyte signal cannot be differentiated from the background noise. It is calculated by dividing the calibration slope by 3 times the standard deviation of the blank signals.
The LOD indicates the presence or absence...
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相关实验视频

Updated: Jul 28, 2025

The Deese-Roediger-McDermott DRM Task: A Simple Cognitive Paradigm to Investigate False Memories in the Laboratory
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弥合虚假发现差距的差距

Arya Ebadi1, Jack Freestone1, William S Noble2,3

  • 1School of Mathematics and Statistics F07, University of Sydney, Sydney, New South Wales 2006, Australia.

Journal of proteome research
|June 1, 2023
PubMed
概括
此摘要是机器生成的。

在使用目标诱竞争 (TDC) 的蛋白质组学实验中控制错误发现率 (FDR),可能无法在特定分析中保证低错误发现比例 (FDP). 像FDP Stepdown和TDC Uniform Band这样的新方法可以更好地控制实证FDP.

关键词:
错误发现比例 错误发现比例错误发现率 错误发现率类检测检测的检测.目标-诱竞争目标-诱竞争

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科学领域:

  • 蛋白质组学是指蛋白质组学.
  • 生物信息学是一种生物信息学.
  • 统计分析 统计分析

背景情况:

  • 串联质谱蛋白质组学实验产生了大量的数据集.
  • 目标诱竞争 (TDC) 是控制虚假发现率 (FDR) 的一种常见方法.
  • 标准的FDR控制方法管理的是错误发现的平均比例,而不是特定数据集中的经验比例.

研究的目的:

  • 要突出蛋白质组学中平均FDR控制和经验错误发现比例 (FDP) 之间的差异.
  • 介绍和解释两个新的统计方法,以改善FDP控制.

主要方法:

  • 使用真实蛋白质组学数据展示FDR与FDP现象.
  • 描述FDP阶段式方法用于控制经验FDP在指定的置信级别.
  • 解释TDC统一带方法,用于提供FDP上限.

主要成果:

  • 实际数据分析证实,平均FDR控制并不能保证低经验FDP.
  • 据证明,FDP阶段化方法有效控制了经验FDP.
  • TDC 统一带为 FDP 提供了统计学上可靠的信任度.

结论:

  • 蛋白质组学中的标准FDR控制可以在实践中导致高于预期的错误发现比例.
  • 根据FDP Stepdown和TDC Uniform Band方法,可以更可靠地控制错误发现的实际数量.
  • 这些新方法提高了质谱蛋白质组学发现的可靠性.