在非固体和固体移植接受者中,复发性慢性鼻炎的危险因素
Estephania Candelo1, Ashley Darakjian2, Karol Avila-Castano3
1Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Jacksonville, FL, USA.
American journal of rhinology & allergy
|June 1, 2023
概括
固体器官移植接受者与非固体器官移植患者相比,面临更高的慢性鼻炎风险,需要内镜外科手术 (ESS). 免疫抑制和排斥是移植受体中强迫性CRS的关键风险因素.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 移植手术 移植手术
- 免疫学 免疫学 免疫学
背景情况:
- 移植接受者是免疫受损的,增加了手术风险.
- 在固体器官移植与非固体器官移植中比较慢性鼻炎 (CRS) 发生率的证据有限.
- CRS是一种常见的并发症,影响了移植患者的生活质量.
研究的目的:
- 为了比较固体和非固体器官移植接收者之间需要内镜鼻手术 (ESS) 的CRS发病率.
- 为了确定这些人群中与反抗性CRS相关的风险因素.
- 根据移植类型分析ESS发病率的差异.
主要方法:
- 在一个多站点的高等学术中心进行回顾性队列研究.
- 在2017-2022年期间,对1303名患有CRS的移植接受者进行了图表审查.
- 对接受ESS的224名患者的分析,对固体 vs 非固体移植进行亚组分析.
主要成果:
- 17.19%的所有移植接受者需要ESS.
- 固体器官移植的接受者有较高的ESS发病率 (57%) 与非固体器官 (28.2%) 相比.
- 在实体移植接受者 (p=0.0005) 中,需要ESS的反抗性CRS的风险是1.78倍 (p=0.0005).
- 免疫疗法,全细胞减小和排斥与两组ESS风险相关.
结论:
- 固体器官移植接受者与非固体器官移植接受者相比,患有需要ESS的CRS的风险要高得多.
- 特殊的风险因素,如免疫疗法,全细胞减小和排斥,需要进一步调查与移植相关的CRS.
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