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Updated: Jul 28, 2025

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions
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Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

Published on: August 27, 2014

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酶触发的DNA传感器技术用于空间控制的,细胞选择性的分子成像.

Mengyuan Li1, Lele Li2,3

  • 1School of Chemistry and Biological Engineering, Beijing Key Laboratory for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing 100083, China.

Accounts of chemical research
|June 1, 2023
PubMed
概括

这项研究引入了由酶触发的DNA传感器,用于在特定细胞类型中精确的分子成像. 这些先进的DNA生物传感器通过使用与疾病相关的酶来控制空间感应来克服传统传感器的局限性,从而改善疾病诊断.

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相关概念视频

Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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