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相关概念视频

Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
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Antigen Processing Pathways01:31

Antigen Processing Pathways

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MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation
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在现场聚合介导的抗原呈现

Chao Pan1, Lu Wang1, Mengmeng Zhang1

  • 1Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Journal of the American Chemical Society
|June 1, 2023
PubMed
概括
此摘要是机器生成的。

一种新的局部聚合介导抗原呈现 (IPAP) 方法通过将纳米疫苗固定在树突细胞上来增强适应性免疫力. 这种方法改善了抗原呈现,并引起了强大的免疫反应来免疫疾病.

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科学领域:

  • 免疫学
  • 纳米技术
  • 生物材料

背景情况:

  • 适应性免疫依赖于有效的抗原呈现细胞激活.
  • 常规策略通常显示低于最佳的抗原特异性原始化.
  • 需要改进的方法来增强抗原呈现和免疫反应.

研究的目的:

  • 开发和评估在现场聚合介导的抗原呈现 (IPAP) 以增强适应性免疫力.
  • 研究IPAP改善树突细胞抗原呈现的机制.
  • 评估IPAP在引起针对瘤和病毒抗原的特异性免疫反应中的有效性.

主要方法:

  • 通过局部多巴胺聚合形成的带抗原的纳米疫苗的开发.
  • 纳米疫苗在体内固定在树突细胞上.
  • 对抗原吸收,降解和呈现的评估.
  • 在小鼠模型中评估免疫反应,包括细胞和幽默免疫.
  • 使用卵泡蛋白和SARS-CoV-2尖端蛋白S1亚单元测试IPAP.

主要成果:

  • IPAP自发地形成纳米疫苗,在体内固定在树突细胞上.
  • 化学结合的纳米疫苗增强了巨细胞分裂并减少了抗原降解.
  • IPAP延长了注射部位的抗原保留时间,并改善了淋巴结的积累.
  • 对表达卵蛋白的瘤观察到显著的保护性免疫力.
  • 使用SARS-CoV-2尖端蛋白S1亚单元实现了S1特异性免疫球蛋白G的增加.

结论:

  • IPAP提供了一种简单多用途的激发抗原呈现细胞的策略.
  • 这种方法有效地增强了抗原特异性适应性免疫反应.
  • IPAP提供了一种对各种疾病的免疫方法.