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没有配方剂的草甘会影响南非爪Xenopus laevis的胚胎发育

Hannah Flach¹, Petra Dietmann¹, Matthias Liess²

¹Institute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

Ecotoxicology and environmental safety

|June 1, 2023

概括

草药草甘 (GLY) 对青胚胎发育产生负面影响,影响其形态,移动性以及心脏和神经系统. 环境相关的GLY度对自然水域的两动物生存构成风险.

科学领域:

环境毒理学环境毒理学
发育生物学是发展生物学.
两动物研究研究

背景情况:

草甘 (GLY) 是一种广泛使用的除草剂.
其已知的机制针对植物特定的途径,表明对非标生物的毒性较低.
然而,GLY已经证明对包括两动物在内的各种非目标生物产生不良影响.

研究的目的:

调查GLY无配方剂对Xenopus laevis胚胎发生的作用.
详细说明GLY对早期发育阶段的具体影响.

主要方法:

对Xenopus laevis胚胎的GLY暴露.
评估形态变化 (身体长度,头部/眼睛尺寸).
在44/45阶段对运动,神经发育和心脏发育的评估.

主要成果:

GLY治疗改变了的形态,包括身体长度和头部/眼睛大小.
胚胎的移动性,神经和心脏发育因GLY暴露而受损.
观察到头骨神经和心脏的结构变化,影响心肌细胞分化.

结论:

即使没有配方剂,GLY在环境相关和最坏情况下也会对Xenopus laevis的胚胎发育产生负面影响.
这些发现表明两动物在水生环境中的生存存在重大风险.
未来关于GLY的监管决策应纳入其对两动物的环境影响.

关键词:

心脏发育的心脏发育胚胎发生是胚胎发生.杀草剂是一种除草剂.神经发育神经发育这是Xenopus.

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